منابع مشابه
Immunology of Vascularized Composite Allografts
Copyright © 2013 Gerald Brandacher et al. This is an open access article distributed under the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original work is properly cited. Over the past decade, vascularized composite allotransplan-tation (VCA), such as hand and face transplantation, has become a clinical realit...
متن کاملVascularized Composite Allografts: Procurement, Allocation, and Implementation
Vascularized composite allotransplantation is a continuously evolving area of modern transplant medicine. Recently, vascularized composite allografts (VCAs) have been formally classified as 'organs'. In this review, key aspects of VCA procurement are discussed, with a special focus on interaction with the procurement of classical solid organs. In addition, options for a matching and allocation ...
متن کاملFor Vascularized Composite Allografts: The Elephant in the Room
W e are well into the era of solid organ transplantation for the preservation of life. Now, with a paradigm shift, we are entering an era of transplantation of parts not necessarily essential for physical survival. As we consider transplants designed to improve quality of life, we must address the elephant in the room for vascularized composite allograft, the cost of immunosuppression. The 5-ye...
متن کاملVASCULARIZED COMPOSITE ALLOGRAFTS (LC CENDALES, SECTION EDITOR) Preclinical Models in Vascularized Composite Allotransplantation
Vascularized composite allotransplantation (VCA) has the potential to reconstruct any non-visceral tissue defect, using like for like tissue, delivering optimal form and function. Over 150 VCA transplants have been performed worldwide; however, this treatment remains experimental. Things systematically tried in the clinic should follow thorough science and tested in a model that allows predicti...
متن کاملChimerism-Based Experimental Models for Tolerance Induction in Vascularized Composite Allografts: Cleveland Clinic Research Experience
The preclinical experimental models of vascularized composite allografts (VCAs) have been rapidly developed for the assessment of immunomodulatory protocols for clinical application. Recently, researchers have focused on immunomodulatory protocols which overcome the immunologic barrier between the allogeneic donor and recipient and may lead to tolerance induction. In order to test the feasibili...
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ژورنال
عنوان ژورنال: Plastic and Reconstructive Surgery - Global Open
سال: 2016
ISSN: 2169-7574
DOI: 10.1097/gox.0000000000001002